Journal: Animals : an Open Access Journal from MDPI

Article Title: Antimicrobial Peptides from Black Soldier Fly ( Hermetia illucens ) as Potential Antimicrobial Factors Representing an Alternative to Antibiotics in Livestock Farming

doi: 10.3390/ani11071937

Figure Lengend Snippet: Mechanism of action of antimicrobial peptides on bacterial cells. This figure presents a scheme of the models of action of AMPs: binding to the bacterial cell membrane (Part 1), possible effect resulting in the destruction of bacterial cell membrane (Part 2) and interactions of AMPs with intracellular substances (Part 3). Part 1: AMPs bind to lipopolysaccharides (LPS) of Gram-negative bacteria and to lipoteichoic or teichoic acid of Gram-positive bacteria and penetrate the cell wall. Part 2: Then the AMPs destroy the membrane structure via four pathways ( a ) toroidal model, ( b ) carpet-like model, ( c ) barrel-stave model, and ( d ) unstructured ring pores. Part 3: antibacterial activity of AMPs is mediated by interactions with heat shock proteins, DNA and RNA.

Article Snippet: However, exploration of AMPs from BSF is in early stages, and investigations of the mechanisms by which BSF-derived AMPs inhibit pathogenic bacteria and interact with the resistance genes are lacking, although some studies on AMP extraction from Hermetia illucens and antibacterial activities have been carried out.

Techniques: Binding Assay, Membrane, Bacteria, Activity Assay